| Autor: |
Lutsenko, Svetlana, Petrukhin, Konstantin, Cooper, Matthew J., Gilliam, Conrad T., Kaplan, Jack H. |
| Zdroj: |
Journal of Biological Chemistry; July 1997, Vol. 272 Issue: 30 p18939-18944, 6p |
| Abstrakt: |
N-terminal domains of the Wilson's and Menkes disease proteins (N-WND and N-MNK) were overexpressed in a soluble form in Escherichia colias fusions with maltose-binding protein, purified, and their metal-binding properties were characterized. Both N-MNK and N-WND bind copper specifically as indicated by the results of metal-chelate chromatography, direct copper-binding measurements, and chemical modification of Cys residues in the presence of different heavy metals. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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