Outcomes in patients treated with chimeric antigen receptor T-cell therapy who were admitted to intensive care (CARTTAS): an international, multicentre, observational cohort study

Autor: Azoulay, Élie, Castro, Pedro, Maamar, Adel, Metaxa, Victoria, de Moraes, Alice Gallo, Voigt, Louis, Wallet, Florent, Klouche, Kada, Picard, Muriel, Moreau, Anne-Sophie, Van De Louw, Andry, Seguin, Amélie, Mokart, Djamel, Chawla, Sanjay, Leroy, Julien, Böll, Boris, Issa, Nahema, Levy, Bruno, Hemelaar, Pleun, Fernandez, Sara, Munshi, Laveena, Bauer, Philippe, Schellongowski, Peter, Joannidis, Michael, Moreno-Gonzalez, Gabriel, Galstian, Gennadii, Darmon, Michael, Valade, Sandrine, Zafrani, Lara, Mariotte, Eric, Lemiale, Virginie, Arnulf, Bertrand, Boissel, Nicolas, Thieblemont, Catherine, Rabian, Florence, Harel, Stéphanie, Di Blasi, Roberta, Delgado, Julio, Ortiz, Valentin, Blaise, Didier, Fürst, Sabine, Legrand, Faezeh, Chabannon, Christian, Forcade, Edouard, Gros, François-Xavier, Borel, Cécile, Huynh, Anne, Récher, Christian, Rudzki, Jakob, Rakszawski, Kevin, Sesques, Pierre, Bachy, Emmanuel, Salles, Gilles, Perales, Miguel A, Wohlfarth, Philipp, Staudingert, Thomas, Jäger, Ulrich, Cartron, Guillaume, Fégueux, Nathalie, Ceballos, Patrice, Platon, Laura, Gastinne, Thomas, Tessoulin, Benoit, Le Bourgeois, Amandine, Gavrilina, Olga, Sureda, Anna, Mussetti, Alberto, Borrega, Jorge Garcia, Borchmann, Peter, Lin, Yi, Benjamin, Reuben, de Guibert, Sophie, Quelven, Quentin, Yakoub-Agha, Ibrahim, Beauvais, David, Rubio, Marie-Therese
Zdroj: The Lancet Haematology; May 2021, Vol. 8 Issue: 5 pe355-e364, 10p
Abstrakt: Chimeric antigen receptor (CAR) T-cell therapy can induce side-effects such as cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome (ICANS), which often require intensive care unit admission. The aim of this study was to describe management of critically ill CAR T-cell recipients in intensive care.
Databáze: Supplemental Index