| Autor: |
Krueger, Joanna K., Padre, Roanna C., Stull, James T. |
| Zdroj: |
Journal of Biological Chemistry; July 1995, Vol. 270 Issue: 28 p16848-16853, 6p |
| Abstrakt: |
Ca2+/calmodulin activates myosin light chain kinase by reversal of an autoinhibited state. The effects of substitution mutations on calmodulin activation properties implicate 4 of the 8 basic residues between the catalytic core and the calmodulin-binding domain in maintaining autoinhibition. These residues are further amino-terminal to the basic residues comprising the previously proposed pseudosubstrate sequence and suggest involvement of the connecting region in intrasteric autoinhibition. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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