Mmot1, a New Helix-Loop-Helix Transcription Factor Gene Displaying a Sharp Expression Boundary in the Embryonic Mouse Brain*

Autor: Malgaretti, Nicoletta, Pozzoli, Ombretta, Bosetti, Alessandro, Corradi, Anna, Ciarmatori, Sonia, Panigada, Maddalena, Bianchi, Marco E., Martinez, Salvador, Consalez, G. Giacomo
Zdroj: Journal of Biological Chemistry; July 1997, Vol. 272 Issue: 28 p17632-17639, 8p
Abstrakt: Several genetic factors have been proven to contribute to the specification of the metencephalic-mesencephalic territory, a process that sets the developmental foundation for prospective morphogenesis of the cerebellum and mesencephalon. However, evidence stemming from genetic and developmental studies performed in man and various model organisms suggests the contribution of many additional factors in determining the fine subdivision and differentiation of these central nervous system regions. In man, the cerebellar ataxias/aplasias represent a large and heterogeneous family of genetic disorders.
Databáze: Supplemental Index