| Autor: |
Chantry, David, Vojtek, Anne, Kashishian, Adam, Holtzman, Douglas A., Wood, Christi, Gray, Patrick W., Cooper, Jonathan A., Hoekstra, Merl F. |
| Zdroj: |
Journal of Biological Chemistry; August 1997, Vol. 272 Issue: 31 p19236-19241, 6p |
| Abstrakt: |
We have identified a novel p110 isoform of phosphatidylinositol 3-kinase from human leukocytes that we have termed p110δ. In addition, we have independently isolated p110δ from a mouse embryo library on the basis of its ability to interact with Ha-RasV12in the yeast two-hybrid system. This unique isoform contains all of the conserved structural features characteristic of the p110 family. Recombinant p110δ phosphorylates phosphatidylinositol and coimmunoprecipitates with p85. However, in contrast to previously described p110 subunits, p110δ is expressed in a tissue-restricted fashion; it is expressed at high levels in lymphocytes and lymphoid tissues and may therefore play a role in phosphatidylinositol 3-kinase-mediated signaling in the immune system. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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