| Autor: |
Chicheportiche, Yves, Bourdon, Paul R., Xu, Haoda, Hsu, Yen-Ming, Scott, Hamish, Hession, Catherine, Garcia, Irene, Browning, Jeffrey L. |
| Zdroj: |
Journal of Biological Chemistry; December 1997, Vol. 272 Issue: 51 p32401-32410, 10p |
| Abstrakt: |
The members of the tumor necrosis factor (TNF) family play pivotal roles in the regulation of the immune system. Here we describe a new ligand in this family, designated TWEAK. The mouse and human versions of this protein are unusually conserved with 93% amino acid identity in the receptor binding domain. The protein was efficiently secreted from cells indicating that, like TNF, TWEAK may have the long range effects of a secreted cytokine. TWEAK transcripts were abundant and found in many tissues, suggesting that TWEAK and TRAIL belong to a new group of widely expressed ligands. Like many members of the TNF family, TWEAK was able to induce interleukin-8 synthesis in a number of cell lines. The human adenocarcinoma cell line, HT29, underwent apoptosis in the presence of both TWEAK and interferon-γ. Thus, TWEAK resembles many other TNF ligands in the capacity to induce cell death; however, the fact that TWEAK-sensitive cells are relatively rare suggests that TWEAK along with lymphotoxins α/β and possibly CD30L trigger death via a weaker, nondeath domain-dependent mechanism. |
| Databáze: |
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