Functional Properties of the Separate Subunits of Human DNA Helicase II/Ku Autoantigen*

Autor: Ochem, Alexander E., Skopac, Doris, Costa, Mario, Rabilloud, Thierry, Vuillard, Laurent, Simoncsits, András, Giacca, Mauro, Falaschi, Arturo
Zdroj: Journal of Biological Chemistry; November 1997, Vol. 272 Issue: 47 p29919-29926, 8p
Abstrakt: The Ku antigen consists of two subunits of 70 and 83 kDa and is endowed with both duplex DNA end-binding capacity and helicase activity (human DNA helicase II). HeLa Ku can be isolated fromin vitrocultured human cells uniquely as a heterodimer, and the subunits can be separated by electrophoresis only under denaturing conditions.
Databáze: Supplemental Index