| Autor: |
Kragten, Eddy, Lalande, Isabelle, Zimmermann, Kaspar, Roggo, Silvio, Schindler, Patrick, Müller, Dieter, van Oostrum, Jan, Waldmeier, Peter, Fürst, Peter |
| Zdroj: |
Journal of Biological Chemistry; March 1998, Vol. 273 Issue: 10 p5821-5828, 8p |
| Abstrakt: |
R-(−)-Deprenyl (Selegiline) represents one of the drugs currently used for the treatment of Parkinson's disease. This compound was shown to protect neurons or glias from programmed cell death in a variety of models. The mechanism of action of neuroprotection as well as inhibition of apoptosis remains elusive. CGP 3466 is a structurally related analog of R-(−)-deprenyl that exhibits virtually no monoamine oxidase type B inhibiting activity but is neuroprotective in the picomolar concentration range. We showed specific binding of CGP 3466 to glyceraldehyde-3-phosphate dehydrogenase by affinity binding, by affinity labeling, and by means of BIAcore® technology. Apoptosis assays based on the human neuroblastoma cell line PAJU established the importance of this interaction for mediating drug-induced inhibition of programmed cell death. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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