| Autor: |
Jonsson, H T, Middleditch, B S, Schexnayder, M A, Desiderio, D M |
| Zdroj: |
Journal of Lipid Research; January 1976, Vol. 17 Issue: 1 p1-6, 6p |
| Abstrakt: |
Two novel prostaglandins (PG) have been found in human seminal fluid which had been frozen immediately after collection. They were characterized by combined gas-liquid chromatography-mass spectrometry of various derivatives as 19-hydroxy prostaglandin E1(11, 15, 19-trihydroxy-9-ketoprost-13-enoic acid) and 19-hydroxy prostaglandin E2(11, 15, 19-trihydroxy-9-ketoprosta-5, 13-dienoic acid). They were present in three to five times the quantity of prostaglandins E1and E2. Incubation of seminal fluid for 3 hr at 25 °C reduced levels of 190H-PGEs 2.5-fold and PGE22-fold, while increasing levels of PGAs and PGBs 2-fold. No 190H PGA or 190H PGB was detected in extracts of unincubated fluid. The PGAs, PGBs and their 19-hydroxy analogs are probably artifacts arising metabolically or as a result of classical isolation techniques. |
| Databáze: |
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