| Autor: |
Odintsov, Igor, Mattar, Marissa S., Lui, Allan J.W., Offin, Michael, Kurzatkowski, Christopher, Delasos, Lukas, Khodos, Inna, Asher, Marina, Daly, Robert M., Rekhtman, Natasha, de Stanchina, Elisa, Ganji, Gopinath, Ladanyi, Marc, Somwar, Romel |
| Zdroj: |
Journal of Thoracic Oncology; 20210101, Issue: Preprints |
| Abstrakt: |
NRG1rearrangements produce chimeric ligands that subvert the ERBB pathway to drive tumorigenesis. A better understanding of the signaling networks that mediate transformation by NRG1fusions is needed to inform effective therapeutic strategies. Unfortunately, this has been hampered by a paucity of patient-derived disease models that faithfully recapitulate this molecularly defined cancer subset. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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