| Autor: |
de Gómez Dumm, I N T, de Alaniz, M J T, Brenner, R R |
| Zdroj: |
Journal of Lipid Research; November 1976, Vol. 17 Issue: 6 p616-621, 6p |
| Abstrakt: |
The effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal preparations of rats has been studied. Administration of epinephrine (1 mg/kg body weight) produced a significant decrease in desaturation of [1-14C]=linoleic acid to γ-linolenic acid and of [1-14C]α-linolenic acid to actadeca-6,9,12,15-tetraenoic acid 12 hr after the infection. Lower doses produced a lesser effect on the Δ6-desaturation activity. Epinephrine administration modified the Vmaxof linoleic acid desaturation but not the Km. There was also a slight increase in palmityl desaturation activity. The effect of epinephrine on Δ6-desaturation activity was postulated to be mediated through an enhancement of the intracellular cyclic AMP levels that lead to an increase of a glucose metabolite. This metabolite would inhibit Δ6-desaturation activity. |
| Databáze: |
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| Externí odkaz: |
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