| Autor: |
Manickavasagar, Thubeena, Yuan, Wei, Carreira, Suzanne, Gurel, Bora, Miranda, Susana, Ferreira, Ana, Crespo, Mateus, Riisnaes, Ruth, Baker, Chloe, O’Brien, Mary, Bhosle, Jaishree, Popat, Sanjay, Banerji, Udai, Lopez, Juanita, Bono, Johann de, Minchom, Anna |
| Zdroj: |
Lung Cancer Management; 20210101, Issue: Preprints |
| Abstrakt: |
Aim:We explore HER3 expression in lung adenocarcinoma (adeno-NSCLC) and identify potential mechanisms of HER3 expression. Materials & methods:Tumor samples from 45 patients with adeno-NSCLC were analyzed. HER3 and HER2 expression were identified using immunohistochemistry and bioinformatic interrogation of The Cancer Genome Atlas (TCGA). Results:HER3 was highly expressed in 42.2% of cases. ERBB3copy number did not account for HER3 overexpression. Bioinformatic analysis of TCGA demonstrated that MEK activity score (a surrogate of functional signaling) did not correlate with HER3 ligands. ERBB3RNA expression levels were significantly correlated with MEK activity after adjusting for EGFRexpression. Conclusion:HER3 expression is common and is a potential therapeutic target by virtue of frequent overexpression and functional downstream signaling. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
