| Autor: |
Tang, Qiaosi, Efe, Gizem, Chiarella, Anna M., Leung, Jessica, Chen, Maoting, Yamazoe, Taiji, Su, Zhenyi, Pitarresi, Jason R., Li, Jinyang, Islam, Mirazul, Karakasheva, Tatiana, Klein-Szanto, Andres J., Pan, Samuel, Hu, Jianhua, Natsugoe, Shoji, Gu, Wei, Stanger, Ben Z., Wong, Kwok-K, Diehl, J. Alan, Bass, Adam J., Nakagawa, Hiroshi, Murphy, Maureen E., Rustgi, Anil K. |
| Zdroj: |
Genes & Development; 2021, Vol. 35 Issue: 7-8 p528-541, 14p |
| Abstrakt: |
In this study, Tang et al. investigated how metastasis is regulated by a common hot spot mutation, p53R175H, in esophageal squamous cell carcinoma (ESCC). Using a carcinogen-induced approach in Trp53R172H/−mice to model ESCC, they demonstrate that expression of Survivin, an antiapoptotic protein encoded by BIRC5 increases in the presence of Trp53R172Hand depletion of Survivin specifically decreases Trp53R172H-driven lung metastasis. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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