| Autor: |
Weyepe Lah, Fidèle Castro, Balemaken Missi, Marius, October, Natasha, Betote Didoue, Patrick Herve, Nalova Ikome, Nalova Hermia, Abdou, Jean Pierre, Kopa Kowa, Theodora, Agbor, Gabriel, Tiabou Tchinda, Alembert, Dongo, Etienne |
| Zdroj: |
Natural Product Communications; March 2021, Vol. 16 Issue: 3 |
| Abstrakt: |
Mortality due to microbial diseases continues to be a major problem in many developing countries. The present study aims to evaluate the antibacterial and antioxidant activities of the ethyl acetate extract and some isolated compounds from aerial parts of Echinops gracilis. The phytochemical study resulted in the isolation of a new flavonoid derivative named apigenin-7-O-(4″-feruloyl)-β-D-glucoside (1), together with 2 known compounds: apigenin-7-O-(4″-trans-p-hydroxycinnamoyl)-β-D-glucoside (2), and apigenin-7-O-glucoside (3). Their chemical structures were determined using a combination of NMR and IR spectroscopic and MS techniques, as well as by comparison with literature data. The extract and isolates were evaluated for their antibacterial and antioxydant properties. The EtOAc extract and compounds 1and 2showed the ability to scavenge 2,2′-zino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS) with scavenging concentration (SC50) values of 13.6 ± 0.8 µg/mL, 108.2 ± 4.3 µg/mL, and 28.5 ± 2.2 µg/mL, respectively. In addition, compound 1displayed significant activity against Escherichia coli, Pseudomonas aeruginosa,and Klebsiella pneumonia, with minimum inhibition concentration (MIC) values of 31.2, 15.6, and 31.2 µg/mL respectively. |
| Databáze: |
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