| Abstrakt: |
Published studies of sarcomas using31P MRS suffer from technical limitations that include absence of localization to regions of interest, resulting in heavy contamination with signals from muscle, and poor resolution. This review has shown that, in spite of their limitations, many of these studies provide important leads to indicate the directions that need to be taken to further develop clinical and biologic uses of MRS. The uniqueness of the metabolic information available in vivo in a noninvasive manner using MRS provides a major stimulus to pursue these directions. In particular, the potential of 31P MRS to predict treatment sensitivity and resistance in individual cases could lead to a very cost-beneficial clinical use of this procedure. |
