| Autor: |
Tokgun, PE, Alay, MT, Atli Tekin, S, Güler, N, Tokgun, O, Demiray, A, Karagenc, N, Durak, T, Celik, B, Akca, H |
| Zdroj: |
Balkan Journal of Medical Genetics; March 2021, Vol. 23 Issue: 2 p99-102, 4p |
| Abstrakt: |
Acute myeloid leukemia (AML) was first categorized in 1976 by French, American and British researchers, and divided into eight subgroups (M0 to M7), depending on the cytochemical or histological changes in the leukemic cells. The gene mutations of FLT3-ITD, CEBPAand NPM1are the most common that cooperate together in the prognosis of AML. The CEBPAgene that is a hematopoietic transcription factor, is located on chromosome 19q13.11, and its prevalence is between 5.0 and 14.0% in AML. The patient was referred to our clinic suffering from menorrhagia, unplanned weight loss in a month and low platelet levels, and was diagnosed with AML on clinical and laboratory examination. Here, we report a patient carrying two novel pathogenic mutations that create a frameshift mutation on the CEBPAgene, c.940_941insCCGTCG TGGAGACGA CGAAGG and c.221_222delAC by Sanger sequencing methodology. |
| Databáze: |
Supplemental Index |
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