| Autor: |
Mazumder, Tanoy, Mamun, Imran Parvez, Zaman, Md. Safayat, Islam, A.K.M. Khairul, Chowdhury, Shahjalal, Reza, Md. Sharif, Hussain, Md. Saddam |
| Zdroj: |
Biochemistry and Biophysics Reports; July 2021, Vol. 26 Issue: 1 |
| Abstrakt: |
Our present study was designed to investigate the comparative anti-obesity efficacy of ethanolic extract of Azadirachta indica A. Juss., Trigonella foenum-graecum L., Allium sativumL. and Zingiber officinale Roscoein high fat-induced mice with their total phenolic and flavonoid profile. Total phenolic and flavonoid content were determined by Folin–Ciocalteu's and Aluminium chloride UV method respectively. In our study, 55 healthy mice were separated into 11 groups to take their respective treatments. Lipid and uric acid profile were estimated by using the enzymatic colourimetric method. Ethanolic extract of A. indicacontained the highest phenolic and flavonoid content. A. indicanormal and high fat diet group showed reduced weight gaining tendency than other extract groups. A. indicaat a dose of 400 mg/kg body weight significantly (p < 0.001) reduced serum cholesterol (SC), triglyceride (TG), and uric acid (UA) level than other three extracts when compared with the control group. Thus, a considerable correlation was found between serum uric acid reducing potentials of the present experimental extracts with a lipid-lowering profile. Pathological examination revealed that the average weight of liver and kidney were significantly decreased in A. indicanormal. Results obtained from the present study it can be concluded that ethanolic extract of A. indicapossesses better lipid-lowering efficacy than the other three herbs. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
