Isolate-Dependent Differences in Clinical, Pathological, and Transcriptional Profiles following In Vitroand In VivoInfections with Rickettsia rickettsii

Autor: Galletti, Maria F. B. M., Paddock, Christopher D., Hecht, Joy A., Biggerstaff, Brad J., Ritter, Jana M., Karpathy, Sandor E.
Zdroj: Infection and Immunity; 2021, Vol. 89 Issue: 4 pe00626-20-e00626-20, 200061995p
Abstrakt: Rickettsia rickettsii, the etiological agent of Rocky Mountain spotted fever (RMSF), a life-threatening tick-borne disease that affects humans and various animal species, has been recognized in medicine and science for more than 100 years. Isolate-dependent differences in virulence of R. rickettsiihave been documented for many decades; nonetheless, the specific genetic and phenotypic factors responsible for these differences have not been characterized.
Databáze: Supplemental Index