| Autor: |
Aslamuzzaman, Kazi, M, Smith David, Qing, Zhong, Ping, Dou Q |
| Zdroj: |
Molecular Pharmacology; October 2002, Vol. 62 Issue: 4 p765-71, 7p |
| Abstrakt: |
Prostate cancer cells demonstrate slow growth kinetics and chemoresistance. Tea polyphenols have been shown to exert prostate cancer-preventative effects. Here we report that growth-arrested prostate cancer cells expressed high levels of a hyperphosphorylated Bcl-X(L) in mitochondria. Treatment with tea polyphenols or the major tea component epigallocatechin-3-gallate blocked expression of the hyper-, but not hypophosphorylated Bcl-X(L) in mitochondria, accompanied by cytochrome c release, caspase activation, and apoptosis. Studies using specific inhibitors suggest that tea inhibits p38 mitogen-activated protein kinase and the proteasome activities, leading to inhibition of Bcl-X(L) phosphorylation and induction of prostate cancer cell death. |
| Databáze: |
Supplemental Index |
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