Highly Functionalized Organolithium Reagents for Enantiomerically Pure α-Amino Acid Synthesis

Autor: Kenworthy, M. N., Kilburn, J. P., Taylor, R. J. K.
Zdroj: Organic Letters; January 2004, Vol. 6 Issue: 1 p19-22, 4p
Abstrakt: Highly functionalized l-serine-derived organolithium reagents have been generated and reacted with a variety of electrophiles, delivering novel enantiomerically pure adducts. These adducts were then converted into homochiral amino alcohols and novel nonproteinogenic α-amino acids, including an aspartic acid mimic that has been synthesized in an enantiomerically pure form for the first time.
Databáze: Supplemental Index