| Abstrakt: |
Major causatives for cutaneous leishmaniasis, the most common form of leishmaniasis, in the old world are Leishmania majorand Leishmania tropica. Investigating the leishmanicidal effects of essential oils and preparing their nano/formulation is a promising approach for developing new green drugs. In this study, the ingredients of Cinnamomum zeylanicumessential oil were investigated using GC/MS analysis, and its antioxidant effect was then evaluated using the DPPH assay. Moreover, the leishmanicidal effect of the essential oil against L. majorand L. tropicawas investigated; obtained half-maximal inhibitory concentrations (IC50)s were 16.53 and 7.56 μg/mL. After that, a practical dosage form of C. zeylanicum,i.e., the nanoemulsion with a 52 ± 4 nm droplet size and a low droplet size distribution index (SPAN = 0.97), was prepared. Interestingly, after treatment of both species with nanoemulsion, their viability was reduced to 0%. The prepared nanoformulation could be considered a potent anti-leishmanial agent for other species and in vivostudies. |
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