Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and mu-opioid receptor deficient mice.

Autor: Romberg, R, Sarton, E, Teppema, L, Matthes, H W D, Kieffer, B L, Dahan, A
Zdroj: BJA: British Journal of Anaesthesia; December 2003, Vol. 91 Issue: 6 p862-870, 9p
Abstrakt: Morphine-6-glucuronide (M6G) is a metabolite of morphine with potent analgesic properties. The influence of M6G on respiratory and antinociceptive responses was investigated in mice lacking the micro -opioid receptor (MOR) and compared with morphine.
Databáze: Supplemental Index