| Autor: |
Simpson, E R, Zhao, Y, Bulun, S E, Mendelson, C R, Agarwal, V R |
| Zdroj: |
Endocrine-Related Cancer; December 1997, Vol. 4 Issue: 4 p407-422, 16p |
| Abstrakt: |
The three key stages of breast cancer are initiation, growth and development, and metastasis. The initiating events in breast cancer are genetic and may be either familial or sporadic in origin, the former arising as a consequence of congenital mutations and the latter as a consequence of changes stemming from environmental insults. Whereas the identification of the BRCA1 and 2 genes is a promising start, this work must be considered only the beginning of the search for genetic mutations in breast cancer. Similarly, whereas mutations in suppresser genes such as p53 and RB, or overexpression of oncogenes such as c-erbB2and c-mycoccur relatively frequently in breast cancer, as yet few strategies have been developed to exploit this knowledge, nor has any mutation been described which comes close to being a universal marker of any breast cancer subtype. Following initiation, breast cancer development is driven by hormonal |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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