Dynamics of blaKPC-2Dissemination from Non-CG258 Klebsiella pneumoniaeto Other Enterobacteralesvia IncN Plasmids in an Area of High Endemicity

Autor: Rada, Ana M., De La Cadena, Elsa, Agudelo, Carlos, Capataz, Cesar, Orozco, Nataly, Pallares, Cristian, Dinh, An Q., Panesso, Diana, Ríos, Rafael, Diaz, Lorena, Correa, Adriana, Hanson, Blake M., Villegas, Maria V., Arias, Cesar A., Restrepo, Eliana
Zdroj: Antimicrobial Agents and Chemotherapy; September 2020, Vol. 64 Issue: 12
Abstrakt: Carbapenem-resistant Enterobacterales(CRE) pose a significant threat to global public health. The most important mechanism for carbapenem resistance is the production of carbapenemases. Klebsiella pneumoniaecarbapenemase (KPC) represents one of the main carbapenemases worldwide. Complex mechanisms of blaKPCdissemination have been reported in Colombia, a country with a high endemicity of carbapenem resistance. Here, we characterized the dynamics of dissemination of blaKPCgene among CRE infecting and colonizing patients in three hospitals localized in a highly endemic area of Colombia (2013 and 2015).
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