| Autor: |
Alves, Michel Muálem de Moraes, Arcanjo, Daniel Dias Rufino, Figueiredo, Kayo Alves, Oliveira, Jéssica Sara de Sousa Macêdo, Viana, Felipe José Costa, Coelho, Elvilene de Sousa, Lopes, Glaucia Lais Nunes, Gonçalves, Juan Carlos Ramos, Carvalho, André Luís Menezes, Rizzo, Márcia dos Santos, Chaves, Mariana Helena, Mendonça, Ivete Lopes de, Carvalho, Fernando Aécio de Amorim |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; September 2020, Vol. 64 Issue: 12 |
| Abstrakt: |
In this study, we demonstrated the potential associative effect of combining conventional amphotericin B (Amph B) with gallic acid (GA) and with ellagic acid (EA) in topical formulations for the treatment of cutaneous leishmaniasis in BALB/c mice. Preliminary stability tests of the formulations and in vitrodrug release studies with Amph B, GA, Amph B plus GA, EA, and Amph B plus EA were carried out, as well as assessment of the in vivotreatment of BALB/c mice infected with Leishmania major. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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