Melatonin ameliorates neuropathy in diabetic rats by abating mitochondrial dysfunction and metabolic derangements.

Autor: Magar, Ajit, Devasani, Karan, Majumdar, Anuradha
Zdroj: Endocrine and Metabolic Science; November 2020, Vol. 1 Issue: 3-4
Abstrakt: •Melatonin supplementation per se and in combination with gabapentin improved the symptoms of diabetic neuropathy•Melatonin supplementation resulted in upregulation of expression of genes involved in mitochondrial biogenesis thus correcting the impairments•Melatonin in the higher dose shows noteworthy merit in the treatment of diabetic neuropathy in laboratory animal model of diabetic neuropathy.
Databáze: Supplemental Index