Down-regulation of RB1and TP53as potential predicting biomarkers for castration-resistant prostate cancer (CRPC): Indonesian retrospective cohort study

Autor: Soerohardjo, Indrawarman, Widodo, Irianiwati, Heriyanto, Didik Setyo, Zulfiqqar, Andy, Anwar, Sumadi Lukman
Zdroj: Annals of Medicine and Surgery; December 2020, Vol. 60 Issue: 1 p549-554, 6p
Abstrakt: Androgen deprivation therapy (ADT) has remained the first line strategy for treatment of advanced prostate cancers. Despite the profound efficacy of ADT in preventing clinical remission, 30–50% of advanced prostate cancer will develop resistance to hormonal deprivation therapy. This study aimed to evaluate the potential role of RB1and TP53expressions as biomarkers for predicting time to castration-resistant prostate cancer (CRPC).
Databáze: Supplemental Index