Synthesis of polycyclic spiro-fused indolines viaIBX-mediated cascade cyclization

Autor: Zhang, Zhiguo, Song, Xiaoqing, Li, Guofeng, Li, Xiang, Zheng, Dan, Zhao, Xuna, Miao, Huanran, Zhang, Guisheng, Liu, Lantao
Zdroj: Chinese Chemical Letters; April 2021, Vol. 32 Issue: 4 p1423-1426, 4p
Abstrakt: We report a 2-iodoxybenzoic acid (IBX)-mediated intarmolecular oxidative spiro-fused tandem cyclization reaction of tryptophan analogs bearing an N-arylamides side-chain to rapidly afford polycyclic spiroindolines featuring multiple stereocenters including a quaternary stereocenters under mild reaction conditions.
Databáze: Supplemental Index