| Abstrakt: |
Spinal cord injury results in an acute loss of excitatory drive to spinal motor circuits. Deprived of motor commands from supraspinal regions, spinal motor circuits rely more upon sensory inputs to compensate for the reduced excitatory drive. In the neurologically intact state, sensory inputs to spinal circuits are precisely calibrated by mechanisms such as presynaptic inhibition. However, in the injured state, presynaptic inhibition may act as a barrier to prevent sensory drive to spinal motor circuits. Accordingly, increasing evidence suggests there is a decrease in presynaptic inhibition in the injured spinal cord. This could leave spinal motor circuits susceptible to exaggerated responses to sensory stimuli. Thus, restoring lost motor function following spinal cord injury will require careful consideration of the roles of presynaptic inhibition in motor control in the intact and lesioned spinal cord. |
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