| Autor: |
Westmeier, Jaana, Paniskaki, Krystallenia, Karaköse, Zehra, Werner, Tanja, Sutter, Kathrin, Dolff, Sebastian, Overbeck, Marvin, Limmer, Andreas, Liu, Jia, Zheng, Xin, Brenner, Thorsten, Berger, Marc M., Witzke, Oliver, Trilling, Mirko, Lu, Mengji, Yang, Dongliang, Babel, Nina, Westhoff, Timm, Dittmer, Ulf, Zelinskyy, Gennadiy |
| Zdroj: |
mBio; October 2020, Vol. 11 Issue: 5 |
| Abstrakt: |
Cytotoxic T cells are responsible for the elimination of infected cells and are key players in the control of viruses. CD8+T cells with an effector phenotype express cytotoxic molecules and are able to perform target cell killing. COVID-19 patients with a mild disease course were analyzed for the differentiation status and cytotoxic profile of CD8+T cells. SARS-CoV-2 infection induced a vigorous cytotoxic CD8+T cell response. However, this cytotoxic profile of T cells was not detected in COVID-19 patients over the age of 80 years. Thus, the absence of a cytotoxic response in elderly patients might be a possible reason for the more frequent severity of COVID-19 in this age group than in younger patients. |
| Databáze: |
Supplemental Index |
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