| Autor: |
Martina, Pablo F., Martinez, Mónica, Rivas, Sebastián, Leguizamón, Lorena, Von Specht, Martha, Ferreras, Julián |
| Zdroj: |
Revista Argentina de Microbiologia; July-September 2020, Vol. 52 Issue: 3 p176-182, 7p |
| Abstrakt: |
Cystic fibrosis patients with Burkholderia cepaciacomplex pulmonary infections have high morbidity and mortality. Worldwide, this disease is undergoing substantial epidemiological changes. Advances in the diagnosis and treatment have conditioned an increase in child survival as well as in the proportion of affected adults. In order to know our reality, we refer to an epidemiological study in 64 CF patients during 11 years of surveillance, focusing on infections caused by Burkholderiaspecies. Conventional and automated phenotypic tests, restriction fragment length polymorphism-recA, recAgene sequencing, and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry were applied. Bacterial isolates were also tested for antimicrobial susceptibility patterns. The prevalence of Burkholderia cepaciacomplex was 9.4%. Based on recAgene sequencing, the most common species identified were Burkholderia cenocepacia(67.3%) and Burkholderia vietnamiensis(20.3%). Ceftazidime and meropenem were the most active, inhibiting 53% and 46% of isolates, respectively. This report represents the first systematic study of Burkholderiainfections in our CF population since beginning of monitoring and treatment and highlights the importance of continued longitudinal studies. |
| Databáze: |
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