| Autor: |
Smeets, Bart, Dijkman, Henry B P M, te Loeke, Nathalie A J M, van Son, Jacco P H F, Steenbergen, Eric J, Assmann, Karel J M, Wetzels, Jack F M, Groenen, Patricia J T A |
| Zdroj: |
Nephrology Dialysis Transplantation; December 2003, Vol. 18 Issue: 12 p2524-2533, 10p |
| Abstrakt: |
Thy-1.1 transgenic mice, characterized by ectopic expression of the Thy-1.1 protein on podocytes, spontaneously develop proteinuria and focal glomerulosclerosis (FGS). Injection of a monoclonal antibody (mAb) directed against the Thy-1.1 protein in young transgenic mice induces a massive albuminuria that is followed by an accelerated FGS within 3 weeks. This albuminuria is complement and leukocyte independent. The time course of proteinuria, the pathogenesis of the acute proteinuria and the dose dependency of FGS are unknown. |
| Databáze: |
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