| Autor: |
Moore, J. D., Byrne, R. J., Vedantham, P., Flynn, D. L., Hanson, P. R. |
| Zdroj: |
Organic Letters; November 2003, Vol. 5 Issue: 23 p4241-4244, 4p |
| Abstrakt: |
An efficient strategy for scavenging a host of nucleophiles utilizing an oligomeric bis-acid chloride (OBAC), generated from the ROM polymerization of trans-bicyclo[2.2.1]hept-5-ene-2,3-dicarbonyl dichloride, is described. The reactivity and high load of the OBAC reagent is exploited in the scavenging of amines, alcohols, and thiols that are present in excess following a common benzoylation event. Following the scavenging event, these oligomers can be precipitated with EtOAc and filtered (SiO2), leaving benzoylated nucleophiles in excellent yield and purity. |
| Databáze: |
Supplemental Index |
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