| Autor: |
Nhung, Le Thi Hong, Quyen, Phan Thi, Thuy, Trinh Thi, Tam, Nguyen Thanh, Anh, Nguyen Thi Hoang, Xuan, Do Thi Thanh, Nhiem, Nguyen Xuan, Huu Tai, Bui, Van Kiem, Phan |
| Zdroj: |
Natural Product Communications; August 2020, Vol. 15 Issue: 8 |
| Abstrakt: |
Three dihydrostilbene derivatives (1-3) and 5 neolignans (4-8) were isolated from the ethyl acetate-soluble fraction of Pouzolzia sanguinea. Two new compounds (1and 4) were obtained. Their structures, as well as their absolute configuration, were elucidated by means of high-resolution electrospray ionization mass spectrometry, nuclear magnetic resonance, and circular dichroism spectral data. Compounds 1-8inhibited NO production in lipopolysaccharide-activated BV2 cells with half-maximal inhibitory concentration (IC50) values ranging from 22.7 ± 1.5 to 61.2 ± 3.1 µM. Of these, compounds 1and 2exhibited the most NO inhibitory activity with IC50values of 22.7 ± 1.5 and 25.1 ± 2.1 µM, respectively, in comparison with the positive control, NG-monomethyl-L-arginine, IC50value 22.1 ± 1.2 µM. |
| Databáze: |
Supplemental Index |
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