Identification of a Potent and Selective 5-HT6 Antagonist:  One-Step Synthesis of (E)-3-(Benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin- 4-ylidenamine from 2-(Benzenesulfonyl)-3,3- bis(methylsulfanyl)acrylonitrile

Autor: Wu, Y.-J., He, H., Hu, S., Huang, Y., Scola, P. M., Grant-Young, K., Bertekap, R. L., Wu, D., Gao, Q., Li, Y., Klakouski, C., Westphal, R. S.
Zdroj: Journal of Medicinal Chemistry; November 2003, Vol. 46 Issue: 23 p4834-4837, 4p
Abstrakt: (E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine (7) was found to be a potent and selective 5-HT6 antagonist. A one-step synthesis of this compound is described.
Databáze: Supplemental Index
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