| Autor: |
de Araújo, Julianna Siciliano, França da Silva, Cristiane, Batista, Denise da Gama Jaén, Nefertiti, Aline, Fiuza, Ludmila Ferreira de Almeida, Fonseca-Berzal, Cristina Rosa, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sijm, Maarten, Kalejaiye, Titilola D., de Koning, Harry P., Maes, Louis, Sterk, Geert Jan, Leurs, Rob, Soeiro, Maria de Nazaré Correia |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; July 2020, Vol. 64 Issue: 9 |
| Abstrakt: |
Pyrazolones are heterocyclic compounds with interesting biological properties. Some derivatives inhibit phosphodiesterases (PDEs) and thereby increase the cellular concentration of cyclic AMP (cAMP), which plays a vital role in the control of metabolism in eukaryotic cells, including the protozoan Trypanosoma cruzi, the etiological agent of Chagas disease (CD), a major neglected tropical disease. In vitrophenotypic screening identified a 4-bromophenyl-dihydropyrazole dimer as an anti-T. cruzihit and 17 novel pyrazolone analogues with variations on the phenyl ring were investigated in a panel of phenotypic laboratory models. |
| Databáze: |
Supplemental Index |
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