Pathogenesis of SIVmac251after atraumatic inoculation of the rectal mucosa in rhesus monkeys

Autor: Pauza, C. David, Emau, Peter, Salvato, Maria S., Trivedi, Parul, MacKenzie, Debra, Malkovsky, Miroslav, Uno, Hideo, Schultz, Kevin T.
Zdroj: Journal of Medical Primatology; February 1993, Vol. 22 Issue: 2-3 p154-161, 8p
Abstrakt: Intrarectal inoculation of rhesus monkeys with low doses of SIVmacled to a prolonged clinical and virological latency that was not observed for high intrarectal doses or for intravenous inoculation. Animals infected intrarectally with low virus doses remained negative for serum antibody responses to SIV for at least one year even though they readily transferred SIV to naive recipients via transfusion of whole blood.
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