Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity

Autor:	Grootenhuis, Peter D.J., Westerduin, Pieter, Meuleman, Dick, Petitou, Maurice, van Boeckel, Constant A.A.
Zdroj:	Nature Structural Biology; September 1995, Vol. 2 Issue: 9 p736-739, 4p
Abstrakt:	Computer modelling of the antithrombin III–heparin–thrombin complex inspired the synthesis of novel glycoconjugates, whose factor Xa and thrombin inhibitory activites can be adjusted in a rational way, leading to anticoagulants with unprecedented characteristics.
Databáze:	Supplemental Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink