| Autor: |
Santos, Amanda R dos, Fraga-Silva, Thais F, F Almeida, Débora de, dos Santos, Rodolfo F, Finato, Angela C, Amorim, Bárbara C, Andrade, Maria I, Soares, Cleverson T, Lara, Vanessa S, Almeida, Nara LM, de Arruda, Olavo S, de Arruda, Maria SP, Venturini, James |
| Zdroj: |
Future Microbiology; 20240101, Issue: Preprints |
| Abstrakt: |
Aim:To investigate the immune response of disseminated Ryzopus oryzaeinfection in immunocompetent mice. Methods:C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/-mice were also evaluated. Results:All mouse strains showed an initial spread of R. oryzaein the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/-mice succumbed to infection within 16 days. Conclusion:This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae. |
| Databáze: |
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