| Autor: |
Motomura, Kenichiro, Romero, Roberto, Xu, Yi, Theis, Kevin R., Galaz, Jose, Winters, Andrew D., Slutsky, Rebecca, Garcia-Flores, Valeria, Zou, Chengrui, Levenson, Dustyn, Para, Robert, Ahmad, Madison M., Miller, Derek, Hsu, Chaur-Dong, Gomez-Lopez, Nardhy |
| Zdroj: |
mBio; June 2020, Vol. 11 Issue: 3 |
| Abstrakt: |
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. Multiple etiologies are associated with preterm birth; however, 25% of preterm infants are born to a mother with intra-amniotic infection, most commonly due to invasion of the amniotic cavity by Ureaplasmaspecies. Much research has focused on establishing a link between Ureaplasmaspecies and adverse pregnancy/neonatal outcomes; however, little is known about the taxonomy of and host response against Ureaplasmaspecies. Here, we applied a multifaceted approach, including human samples, in vivomodels, and in vitromanipulations, to study the maternal-fetal immunobiology of Ureaplasmainfection during pregnancy. Furthermore, we investigated the use of clarithromycin as a treatment for this infection. Our research provides translational knowledge that bolsters scientific understanding of Ureaplasmaspecies as a cause of adverse pregnancy/neonatal outcomes and gives strong evidence for the use of clarithromycin as the recommended treatment for women intra-amniotically infected with Ureaplasmaspecies. |
| Databáze: |
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