| Autor: |
Yi, Chenghao, Li, Jinpeng, Tang, Fuxin, Ning, Zhikun, Tian, Huakai, Xiao, Longlin, Wang, Anan, Zong, Zhen |
| Zdroj: |
The American Surgeon; May 2020, Vol. 86 Issue: 5 p499-507, 9p |
| Abstrakt: |
Objective We aimed to explore the prognostic value of primary tumor and specific metastases excision on survival among patients with stage IV colorectal cancer (CRC) in the Surveillance, Epidemiology, and End Results (SEER) database.Methods Patients with stage IV CRC were selected using SEER database between 2010 and 2013. Survival rate was calculated according to the Kaplan-Meier method, and differences between curves were tested by the log-rank test. Cox proportional hazards model was used in the multivariable analysis.Results Included in this study were 27 878 patients with distant metastatic CRC. Among the single organ site of metastatic CRC, patients with solitary metastasis of lung showed the highest median overall survival (OS). Both primary and metastatic sites surgical resection for patients with liver, lung, and simultaneous liver and lung metastases had better median OS. Age younger than 65 years, Asian and Pacific Islander, distal colon and rectum, and palliative primary tumor and metastatic lesions resection were associated with better OS after multivariate analysis. Palliative primary tumor and metastatic lesions resection had a significant survival benefit compared with nonsurgical group in selected patients.Conclusion These findings support the use of preemptive surgery in the management of highly selected metastatic CRC patients. |
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