Intravenous Aminophylline Therapy for Asthma: A Comparison of Two Methods of Administration in Children

Autor: Goldberg, Paul, Leffert, Fred, Gonzalez, Mario, Gogenola, Larry, Zerbe, Gary O.
Zdroj: American Journal of Diseases of Children; June 1980, Vol. 134 Issue: 6 p596-599, 4p
Abstrakt: • Eleven asthmatic children were given intravenous aminophylline by two methods of administration: a 6 mg/kg loading dose followed by a 1.1 mg/kg/hr continuous infusion, or a bolus of 4 mg/kg given every four hours. Expiratory flow rates (forced expiratory volume at 1 s and expiratory flow at 50% of vital capacity) were recorded at intervals for 24 hours with each regimen. Although the intermittent administration of aminophylline produced a substantial improvement, there was a significantly greater pulmonary response to continuous infusion.(Am J Dis Child 134:596-599, 1980)
Databáze: Supplemental Index