Pathophysiology of Respiratory Distress in Newborn Lambs: Circulatory, Biochemical, and Pathological Considerations

Autor: STAHLMAN, MILDRED, LeQUIRE, V. S., YOUNG, WILLIAM C., MERRILL, ROBERT E., BIRMINGHAM, RUSSELL T., PAYNE, GABE A., GRAY, JAMES
Zdroj: American Journal of Diseases of Children; October 1964, Vol. 108 Issue: 4 p375-393, 19p
Abstrakt: The etiology and pathogenesis of hyaline membrane disease of the newborn are unknown. A number of investigators have been successful in producing lesions resembling hyaline membranes in the lungs of experimental animals.1-6 Although histochemical studies of the lungs have been compared to those of infants dying with hyaline membrane disease, serial clinical, chemical, and physiological correlations with the pathological development of this lesion have not been reported.The respiratory distress syndrome of human newborn infants shows a wide spectrum of severity and does not invariably lead to death with hyaline membrane demonstration. There is a high correlation of this syndrome with prematurity, maternal diabetes, and birth by cesarean section. Complications of pregnancy, especially those that might interfere with blood supply to the fetus, have been implicated.7We have attempted to reproduce the clinical and pathological picture of the respiratory distress syndrome in newborn lambs. These lambs were
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