| Autor: |
Lei, Honghui, Rovis, Tomislav |
| Zdroj: |
Nature Chemistry; 20240101, Issue: Preprints p1-7, 7p |
| Abstrakt: |
C–H activation reactions enable chemists to unveil new retrosynthetic disconnections and streamline conventional synthetic approaches. A long-standing challenge in C–H activation is the inability to distinguish electronically and sterically similar C–H bonds. Although numerous synergistic combinations of transition-metal complexes and chelating directing groups have been utilized to distinguish C–H bonds, undirected regioselective C–H functionalization strategies remain elusive. Here we report a regioselective C–H activation/amination reaction of various unsymmetrical dialkyl-substituted alkenes. The regioselectivity of C–H activation is correlated to the electronic properties of allylic C–H bonds indicated by the corresponding 1JCHcoupling constants. A linear relationship between the difference in the 1JCHcoupling constants of the two competing allylic C–H bonds (Δ1JCH) and the C–H activation barriers (ΔΔG‡) has also been determined. |
| Databáze: |
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