| Autor: |
Wu, Ze Xin, Ma, Wen Zhe, Wang, Lei, Yao, Chang Lin, Song, Shuang, Wang, Xin Yuan |
| Zdroj: |
Materials Science Forum; May 2020, Vol. 993 Issue: 1 p776-784, 9p |
| Abstrakt: |
Telmisartan (TEL), a type of antihypertensive drug, has poor solubility. To improve its solubility, the co-amorphous telmisartan with pimelic acid (PA) in molar ratio of 1:1 and 2:1, respectively, were obtained using a liquid-assisted grinding method. The co-amorphous system was characterized by the powder X-ray diffraction and differential scanning calorimetry. The molecular interactions of the co-amorphous were studied by the infrared spectra. After the formation of co-amorphous, the solubility of TELwas much improved, and the apparent solubility values were approximately 9-15 times as high as that of crystalline TEL. Moreover, the co-amorphous TEL-PA was stored under 25 °C/20% RH for a month without any evidence of conversion by powder X-ray diffraction analysis. |
| Databáze: |
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