| Autor: |
Branquinho, Renata Tupinambá, de Mello, Carlos Geraldo Campos, Oliveira, Maykon Tavares, Reis, Levi Eduardo Soares, Vieira, Paula Mello de Abreu, Saúde-Guimarães, Dênia Antunes, Mosqueira, Vanessa Carla Furtado, de Lana, Marta |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; March 2020, Vol. 64 Issue: 4 |
| Abstrakt: |
Chagas disease remains neglected, and current chemotherapeutics present severe limitations. Lychnopholide (LYC) at low doses loaded in polymeric poly(d,l-lactide)-block-polyethylene glycol (PLA-PEG) nanocapsules (LYC-PLA-PEG-NC) exhibits anti-Trypanosoma cruziefficacy in mice infected with a partially drug-resistant strain. This study reports the efficacy of LYC-PLA-PEG-NC at higher doses in mice infected with a T. cruzistrain resistant to benznidazole (BZ) and nifurtimox (NF) treated at both the acute phase (AP) and the chronic phase (CP) of infection by the oral route. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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