| Autor: |
Rotondo, Caitlyn M., Sychantha, David, Koteva, Kalinka, Wright, Gerard D. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; March 2020, Vol. 64 Issue: 4 |
| Abstrakt: |
The rise of Gram-negative pathogens expressing metallo-β-lactamases (MBLs) is a growing concern, threatening the efficacy of β-lactam antibiotics, in particular, the carbapenems. There are no inhibitors of MBLs in current clinical use. Aspergillomarasmine A (AMA) is an MBL inhibitor isolated from Aspergillus versicolorwith the ability to rescue meropenem activity in MBL-producing bacteria both in vitroand in vivo. Here, we systematically explored the pairing of AMA with six β-lactam antibiotic partners against 19 MBLs from three subclasses (B1, B2, and B3). |
| Databáze: |
Supplemental Index |
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