| Autor: |
Pelosi, Ludovic, Vo, Chau-Duy-Tam, Abby, Sophie Saphia, Loiseau, Laurent, Rascalou, Bérengère, Hajj Chehade, Mahmoud, Faivre, Bruno, Goussé, Mathieu, Chenal, Clothilde, Touati, Nadia, Binet, Laurent, Cornu, David, Fyfe, Cameron David, Fontecave, Marc, Barras, Frédéric, Lombard, Murielle, Pierrel, Fabien |
| Zdroj: |
mBio; July 2019, Vol. 10 Issue: 4 |
| Abstrakt: |
In order to colonize environments with large O2gradients or fluctuating O2levels, bacteria have developed metabolic responses that remain incompletely understood. Such adaptations have been recently linked to antibiotic resistance, virulence, and the capacity to develop in complex ecosystems like the microbiota. Here, we identify a novel pathway for the biosynthesis of ubiquinone, a molecule with a key role in cellular bioenergetics. We link three uncharacterized genes of Escherichia colito this pathway and show that the pathway functions independently from O2. In contrast, the long-described pathway for ubiquinone biosynthesis requires O2as a substrate. In fact, we find that many proteobacteria are equipped with the O2-dependent and O2-independent pathways, supporting that they are able to synthesize ubiquinone over the entire O2range. Overall, we propose that the novel O2-independent pathway is part of the metabolic plasticity developed by proteobacteria to face various environmental O2levels. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
