| Autor: |
Furusawa, Yuri, Yamada, Shinya, da Silva Lopes, Tiago Jose, Dutta, Jayeeta, Khan, Zenab, Kriti, Divya, van Bakel, Harm, Kawaoka, Yoshihiro |
| Zdroj: |
mBio; October 2019, Vol. 10 Issue: 5 |
| Abstrakt: |
The reverse genetics method of influenza virus generation has enabled us to generate recombinant viruses bearing modified viral proteins. Recombinant influenza viruses expressing foreign genes have become useful tools in basic research, and such viruses can be utilized as efficient virus vectors or multivalent vaccines. However, the insertion of a foreign gene into the influenza virus genome often impairs virus replication, and the inserted genes are unstable. Elucidation of the mechanisms of foreign gene stabilization will help us to establish useful recombinant influenza viruses. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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