Small-Molecule Morphogenesis Modulators Enhance the Ability of 14-Helical β-Peptides To Prevent Candida albicansBiofilm Formation

Autor: Rodríguez López, Angélica de L., Lee, Myung-Ryul, Wang, Nathan B., Dunn, Kaitlin K., Sanchez, Hiram, Raman, Namrata, Andes, David R., Lynn, David M., Palecek, Sean P.
Zdroj: Antimicrobial Agents and Chemotherapy; June 2019, Vol. 63 Issue: 9
Abstrakt: Candida albicansis an opportunistic fungal pathogen responsible for mucosal candidiasis and systemic candidemia in humans. Often, these infections are associated with the formation of drug-resistant biofilms on the surfaces of tissues or medical devices. Increased incidence of C. albicansresistance to current antifungals has heightened the need for new strategies to prevent or eliminate biofilm-related fungal infections.
Databáze: Supplemental Index